Novavax Vaccine

Science • Medicine
Novavax vaccine up to 96% effective in UK trial
Novavax vaccine up to 96% effective in UK trial
Credit: Novavax

American vaccine development company Novavax said its Covid-19 vaccine has shown a 96% efficacy against the original Coronavirus strain and a 86% efficacy against the more potent UK strain B117 in Phase 3 clinical trials in the United Kingdom. The vaccine has also shown to be 100% effective against severe Covid-19 infections.

Trials are still running in the United States, and the company will apply for US emergency use authorization as soon as those trials are complete.

Stanley Erck, Novavax's president and CEO, said that the company was "very encouraged by the data".

“We are very encouraged by the data showing that NVX-CoV2373 not only provided complete protection against the most severe forms of disease, but also dramatically reduced mild and moderate disease across both trials. Importantly, both studies confirmed efficacy against the variant strains,” so Erck. “Today marks one year since the WHO officially declared the COVID-19 pandemic, and with this data in hand, we are even more motivated to advance our vaccine as a potential weapon in the fight to end the suffering caused by COVID-19.”

Novavax Covid-19 vaccine shows 85.6% efficacy
Novavax Covid-19 vaccine shows 85.6% efficacy
Credit: Illustration by Ashley Winkler for Pendect (Creative Commons Attribution ShareAlike 4.0)

A trial conducted in the United Kingdom showed that Novavax's Covid-19 vaccine was 95.6% effective against the original Covid-19 strain and 85.6% effective against the new mutation B.1.1.7 that first was discovered in the UK. The vaccine however only showed a 60% efficacy against the mutation first identified in South Africa.

The company's vaccine, known as NVX-CoV2373, "is the first vaccine to demonstrate not only high clinical efficacy against COVID-19 but also significant clinical efficacy against both the rapidly emerging UK and South Africa variants," Stanley Erck, Novavax president and CEO, said in an announcement. "NVX-CoV2373 has the potential to play an important role in solving this global public health crisis," he said.