University of Bern

Scientists have developed a synthetic blood-thinner without bleeding side-effects
Bleeding wound on finger
Bleeding wound on finger Credit: Crystal (Crystl) from Bloomington, USA (Creative Commons Attribution 2.0)

Researchers at the Swiss Federal Institute of Technology Lausanne have developed the first synthetic blood-thinner. Together with three other laboratories, the Laboratory of Therapeutic Proteins and Peptides of Professor Christian Heinis has developed an inhibitor that stays in the blood plasma for over 120 hours and shows high potency, stability and selectivity.

Together with the University Hospital of Bern (Inselspital) and the University of Bern they've shown that the new blood-thinner can efficiently block coagulation in a thrombosis model without the increased risk of bleeding side effects present in currently used blood-thinners.

Professor Christian Heinis has stated that "our collaboration found that it is possible to achieve bleeding-free anti-coagulation with a synthetic inhibitor". According to him, the "inhibitor is a promising candidate for safe thromboprotection in artificial lungs" and will undergo further studies and optimizations.