New Covid-19 mutation in California worries researchers

A corona mutation is circulating in California and other U.S. states that could be more contagious and dangerous. The data situation is still unclear, but some things seem worrying.

Now another mutation has emerged in California, it has already spread to other U.S. states and has also been detected in countries such as Australia, Denmark and Mexico. It was first discovered in December, reports the journal Science. Investigations suggest that this variant of Sars-CoV-2 could not only be more contagious but probably also takes more violent courses. According to this, intensive medical care and deaths occur more frequently - however, the data situation here is still very thin.

The researchers call the variants B.1.427 and B.1.429 - it occurs with slightly different mutations. Under a different naming scheme, it is also known as 20C/L452R.

B.1.427 / B.1.429 carries several mutations, but three seem to be particularly relevant. They affect the spike protein that the virus uses to dock with human cells. Mutation L452R, in particular, appears to increase infectivity. It apparently stabilizes the interaction between the spike protein and the receptor used by the virus. None of the three spike mutations are found in the virus variants from Great Britain, South Africa and Brazil.